Intraocular pressure sensor implant

We all share a common goal: Making products that help to improve the medical treatment of glaucoma patients and hence retain or even improve quality of life both for them and their families.

At the technological forefront

Cicor is producing a flexible coil antenna for an intraocular pressure sensor implant made by German company Implandata Ophthalmic Products GmbH. The antenna is used for transmitting and receiving data, as well as supplying power to the microsensor that wirelessly measures intraocular pressure.


Implandata Ophthalmic Products GmbH is a young medical device company based in Hanover. It is a technological leader in using wireless telemetry to measure pressure and other bodily parameters. The technology platform is a cooperative development with Fraunhofer Gesellschaft e.V., an institution renowned worldwide for its application-oriented research.

The intraocular pressure sensor implant will be used in opthalmology, in particular for glaucoma patients. A novel, implantable extraocular sensor that can measure intraocular pressure for 24 hours, the implant is fitted together with an artificial eye lens used to treat cataracts (lenticular opacity). The reason for this is that glaucoma and cataracts are two diseases that often go hand in hand.

The microsensor enables near real-time monitoring of how the disease and therapeutic countermeasures are progressing. Patients can easily perform measurements with an external hand held device themselves in the comfort of familiar surroundings.

Straightforward, frequent measurement of patients' intraocular pressure gives ophthalmologists early feedback on the effectiveness of treatment and whether adjustments are needed. This can avoid further loss of vision resulting from uncontrolled intraocular pressure.

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Demands on material and manufacturing technology

 

Developing and manufacturing the coil antenna for powering the microsensor in a form that would be compatible with its
intended application presented a major challenge. Made from gold, the finished coil is 18–20 μm thick with an exceptionally
fine structure (lines 40 μm wide, separated by 20 μm). Designed to minimize electrical resistance, this relatively thick metalization in terms of the separation distance is especially demanding to produce. Subsequently assembling components onto the flexible substrate also calls for a great deal of know-how.


Cicor is a leading manufacturer of sophisticated microelectronics and high-quality substrates. In the area of microelectronics, we offer state-of-the-art assembly and interconnect technologies as well as packaging technologies, while the manufacture of highly complex rigid, rigid-flex and flex circuit boards and thin- and thick-film interconnect devices is what marks us out from the competition in the area of substrate manufacturing and processing.


Experience, technological capability and top quality are crucial to sophisticated solutions. These are the values by which we stand, as a reliable partner to businesses such as Implandata Ophthalmic Products GmbH.

Huge manufacturing expertise in tiny structures

 

The cooperatively developed intraocular pressure sensor is based on a flexible polyimide-based thin-film substrate. Cicor produces this base substrate in-house by applying polyimide to a ceramic carrier and then structuring it in the shape of the coil bobbin. The coil is held in place only by small, insular surfaces beneath the coil's windings, which assure the mechanical integrity of the structure. This makes for problem-free encapsulation in silicone, resulting in a long-life implant.


The complex sensor functions are integrated on a custom-developed ASIC chip that is applied to the substrate using thermocompression. The structured and assembled substrate is then released from its ceramic carrier and encapsulated in medical-grade silicone for biocompatibility.


Dependable production processes and maintaining tolerances are both central to manufacturing the product. Strict process control ensures production of the highest caliber, benefiting our customers and not least patients' health.

The path to innovative solutions

The challenge

  • Reliability and functionality
    • High degree of reliability and precision, considering the device's Long-term deployment in the human eye
    • Low or Zero defect density
    • Interference resistance
  • New product development
    • Implementation of novel technological processes
    • Involvement in the development of a new medical device
  • Miniaturization
    • Precise structuring to tight tolerances
    • Small, flexible, highly complex design
  • Technical requirements
    • Complex conduxtor path geometry
    • Demanding assembly onto a flexible substrate

Requirements

  • Materials
    • Polyimide
    • Gold
    • Biocompatible, Long-Lasting materials
  • Precision
    • Stable processes
    •  Technology know-how
    •  Maximum cleanliness
  • Quality
    • Guaranteed product Quality
    • Near-zero fault tolerance
  • Experience
    • Cutting-edge technologies
    • Competent personnel
    • Top development expertise
  • Partnership

The Cicor solution

  • Flexible, polyimide-based thin-film substrate
  • Biocompatible materials
  • Joint new product development
  • Near-Zero fault tolerance
  • Complex microassembly

Benefits

for Implandata Ophthalmic Products GmbH
  • Service from a single source: from development to mass production
  • A partner with experience in substrate manufacturing, assembly and interconnect technologies
  • Exploitation of synergies in product development
  • State-of-the-art production facilities
  • Innovative Technologies - engineered for top reliability
for the end customer
  • Enables first-ever long-term Monitoring of intraocular pressure
  • Easy read-out by the patient
  • Increased quality of life
  • Decreased risk of blindness
  • Maximum wearing comfort